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Year : 2016  |  Volume : 1  |  Issue : 1  |  Page : 39-41

Clinical relevance of hypothyroidism screening in a child with an unexplained elevated serum creatinine

Department of Pediatrics, College of Medicine, Al-Imam Muhammad Ibn Saud Islamic University, Riyadh, Saudi Arabia

Correspondence Address:
Dr. Hassan Alshehri
Department of Pediatrics, College of Medicine, Al-Imam Muhammad Ibn Saud Islamic University, Otham Ibn Affan Road, PO Box 7544, Riyadh 13317-4233
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

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The association of hypothyroidism with a reduction in glomerular filtration rate and renal plasma flow is widely mentioned in the literature. However, elevation of serum creatinine (SCr) is not frequently described in the textbooks and literature as an indicator of hypothyroidism. Here, we present a 6-year-old girl who had deprived the energy for vigorous physical activity and reported fatigue to perform her daily activities with no other history of significant medical conditions with unremarkable physical examination. All her initial laboratory findings were within the normal range except an increased SCr level (75 μmol/L). The presence of nonspecific symptoms and unexplained elevation of SCr led to endocrinological investigations, which revealed hypothyroidism caused by autoimmune thyroiditis. Replacement therapy with thyroxine improved her hypothyroid state and SCr level to normal after 6 weeks. Therefore, we recommend measurement of thyroid function in these patients to rule out the likelihood of hypothyroidism.

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