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ORIGINAL ARTICLE
Year : 2019  |  Volume : 4  |  Issue : 1  |  Page : 16-20

Immunochemical evidence of Trypanosoma cruzi and Toxoplasma gondii parasitic infections in human immunodeficiency virus/acquired immunodeficiency syndrome subjects in relationship with the CD4+ count


1 Department of Medical Laboratory Science, Edo University, Iyamho, Nigeria
2 Department of Medical Laboratory Science, Achievers University, Owo, Ondo State, Nigeria

Correspondence Address:
Prof. Mathew Folaranmi Olaniyan
Department of Medical Laboratory Science, Edo University, Iyamho
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijas.ijas_19_18

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Study Background: Trypanosoma cruzi and Toxoplasma gondii parasitic infections in human immunodeficiency virus (HIV)-positive patients could accelerate the progression of HIV infection, which may result into immunosuppression due to immune responses involving cytokines and CD4 + cells. Aim and Objective: This work was designed to determine the immunochemical evidence of T. cruzi and T. gondii parasitic infections in HIV/acquired immunodeficiency syndrome subjects in relationship with the CD4+ count. Materials and Methods: Fifty HIV-positive subjects (25 females and 25 males) aged 14–57 years were recruited as test subjects while 100 HIV-seronegative age-matched individuals were recruited as control. T. cruzi and T. gondii parasitic infections were determined in the subjects by ELISA, while CD4+ cells enumeration was carried out in the subjects by cyflowmetry, and HIV test was carried out by immunochromatography and western blotting. Results: The results obtained showed a significantly lower CD4+ cells in T. cruzi- and T. gondii-infected HIV-positive patients than the HIV-positive and HIV-negative subjects who were not infected with any of the parasites (<0.05). There was also a significantly lower CD4+ cells in T. gondii-infected HIV-positive patients than T. cruzi-infected HIV-positive patients (<0.05). The frequency of T. cruzi in HIV-positive patients was 18% (9) which was more prevalent in male patients (12%[6] vs. 6% [3]) while that of T. gondii-infected HIV-positive patients was 14% (7), was more prevalent in females than males (10%[5] vs. 4% [2]). T. cruzi parasitic infection was found to be more prevalent compared to T. gondii infection among HIV-positive patients (18%[9] vs. 14% [7]). Conclusion: There parasitic infection caused a significant decrease in CD4+ cells in HIV subjects. There was also a gender difference in the parasitic infection of T. cruzi and T. gondii while the frequency of T. cruzi was 18% (9) and T. gondii was 14% (7).


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